![]() ![]() We identified retinoids as robust inducers of 2CLCs and the retinoic acid (RA)-signaling pathway as a key component of the regulatory circuitry of totipotent cells in embryos. Here, we used 2CLCs to perform a small-molecule screen to identify new pathways regulating the 2-cell-stage program. ![]() Such ‘2-cell-like-cells’ (2CLCs) recapitulate 2-cell-stage features and display expanded cell potential. Cells resembling the totipotent cells of early embryos arise spontaneously in mouse embryonic stem (ES) cell cultures. ![]() Thus, the development of cellular models recapitulating totipotent-like features is of paramount importance. Totipotent cells hold enormous potential for regenerative medicine. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. Archives
June 2023
Categories |